Intrinsically Disordered Protein Analysis: Volume 2, Methods and Experimental Tools

✍ Scribed by Ucheor B. Choi, Keith R. Weninger, Mark E. Bowen (auth.), Vladimir N. Uversky, A. Keith Dunker (eds.)

• Publisher: Springer-Verlag New York
• Year: 2012
• Tongue: English
• Leaves: 447
• Series: Methods in Molecular Biology 896
• Edition: 1
• Category: Library

✦ Synopsis

Over the past decade, there has been an explosive development of research of intrinsically disordered proteins (IDPs), which are also known as unfolded proteins. Structural biologists now recognize that the functional diversity provided by disordered regions complements the functional repertoire of ordered protein regions. In Intrinsically Disordered Protein Analysis: Methods and Experimental Tools, expert researchers explorethe high abundance of IDPs in various organisms, their unique structural features, numerous functions, and crucial associations with different diseases. Volume 2 includes sections on single molecule techniques, methods to assess protein size and shape, analyzing conformational behavior, mass-spectrometry, expression and purification of IDP’s. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.

Thorough and intuitive,Intrinsically Disordered Protein Analysis: Methods and Experimental Tools helps scientists further their investigations of these fascinating and dynamic molecules.

✦ Table of Contents

Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Front Matter....Pages 3-20
Front Matter....Pages 21-45
Front Matter....Pages 47-56
Front Matter....Pages 57-69
Front Matter....Pages 71-87
Back Matter....Pages 89-89
....Pages 91-105

✦ Subjects

Protein Science; Protein Structure