Intrinsically Disordered Proteins

✍ Scribed by Vladimir N. Uversky (auth.)

Publisher: Springer International Publishing
Year: 2014
Tongue: English
Leaves: 73
Series: SpringerBriefs in Molecular Science - Protein Folding and Structure
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.

✦ Table of Contents

Front Matter....Pages i-xv
Intrinsically Disordered Proteins....Pages 1-51
Back Matter....Pages 53-61

✦ Subjects

Protein Structure; Medicinal Chemistry; Biochemistry, general

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