Intrinsic B lymphocyte defect in untreated patients with Hodgkin's disease
β Scribed by Frank Griesinger; Lothar Bergmann; Rita Barot-Ciorbaru; Paris S. Mitrou
- Publisher
- Springer-Verlag
- Year
- 1990
- Tongue
- English
- Weight
- 754 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0340-7004
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The prevalence of complement dependent, cold-reactive lymphocytotoxic serum factors (LT) was studied in 80 untreated patients with Hodgkin's disease by a microcytotoxicity assay. Sera from 24 patients (30%) contained LT as judged from at least 50% lysis of lymphocytes from 16 of 23 randomly selected
We describe the presence of a high frequency of spontaneous chromosome aberrations in lymphocytes from six untreated patients with Hodgkin's disease. The characteristics of the chromosome abnormalities observed suggest the existence of a certain degree of chromosome instability in these cases, that