Intravenous immunoglobulins (IVIG) are increasingly used in various clinical situations for which they have been considered to be safe and eective. However, since 1987, some cases of renal toxicity have been reported. Forty-nine cases of acute renal failure have been notiยฎed to the French Regional
Intravenous gammaglobulin-associated acute renal failure
โ Scribed by N. Gupta; I. Ahmed; S. Nissel-Horowitz; D. Patel; B. Mehrotra
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 14 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0361-8609
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โฆ Synopsis
Intravenous gammaglobulins are used for the treatment of various auto-immune hematological disorders. Renal failure is a relatively rare, but an increasingly recognized side effect of gammaglobulin therapy. Although the renal failure is usually reversible, renal replacement therapy is required occasionally. A high index of suspicion, early recognition and appropriate intervention can prevent this complication. We herewith describe two patients with an immune hematological disorder, who developed acute renal failure after treatment with intravenous gammaglobulins. A brief review of the possible risk factors, pathophysiology and management of this complication is provided. Am. J. Hematol. 66:151-152, 2001.
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