𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Acute renal failure associated with intravenous immunoglobulins

✍ Scribed by Valérie Gras; Michel Andréjak; Guillaume Decocq

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
84 KB
Volume
8
Category
Article
ISSN
1053-8569

No coin nor oath required. For personal study only.

✦ Synopsis

Intravenous immunoglobulins (IVIG) are increasingly used in various clinical situations for which they have been considered to be safe and eective. However, since 1987, some cases of renal toxicity have been reported.

Forty-nine cases of acute renal failure have been noti®ed to the French Regional Pharmacovigilance Centers between 1992 and mid 1998. In this series, marked serum creatinine increases (mean 387%+181%) appeared within 8 h to 8 days after initiation of IVIG therapy. Oliguria was observed in 80% of the cases. Haemodialysis was required for 34% of the patients. The renal failure persisted for a mean duration of 10 days after discontinuation of the IVIG treatment. Although risk factors have not been de®nitely established, preexisting renal impairment and old age seem to predispose to IVIGassociated acute renal failure as well as diabetes mellitus or the use of diuretics. The mechanism of renal injury remains speculative but a hyperoncotic overloading may be contributory.

Finally, close monitoring of renal function is required in patients with preexisting renal failure, with older age and with diabetes mellitus.

📜 SIMILAR VOLUMES

Intravenous gammaglobulin-associated acu
Intravenous gammaglobulin-associated acute renal failure
✍ N. Gupta; I. Ahmed; S. Nissel-Horowitz; D. Patel; B. Mehrotra 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 14 KB 👁 1 views

Intravenous gammaglobulins are used for the treatment of various auto-immune hematological disorders. Renal failure is a relatively rare, but an increasingly recognized side effect of gammaglobulin therapy. Although the renal failure is usually reversible, renal replacement therapy is required occas

Hemolytic anemia associated with intrave
Hemolytic anemia associated with intravenous immunoglobulin
✍ John R. Wilson; Nirmala Bhoopalam; Morris Fisher 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 46 KB 👁 2 views

Intravenous immunoglobulin (IVIg) is a useful tool in the treatment of a variety of neuromuscular disorders. Though IVIg therapy is generally safe, hemolytic anemia is a potentially serious complication that is often overlooked, and is currently not listed in product inserts. We analyzed 45 patients