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Intratumoural heterogeneity of 1p deletions andMYCN amplification in neuroblastomas

โœ Scribed by Ambros, P.F. ;Ambros, I.M. ;Kerbl, R. ;Luegmayr, A. ;Rumpler, S. ;Ladenstein, R. ;Amann, G. ;Kovar, H. ;Horcher, E. ;De Bernardi, B. ;Michon, J. ;Gadner, H.


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
552 KB
Volume
36
Category
Article
ISSN
0098-1532

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## Background: We have identified for the first time a homozygously deleted region within the smallest region of overlap at 1p36.2-3 in two neuroblastoma cell lines. ## Procedure: The 800-kb pac contig covering the entire homozygously deleted region was made and sequenced. to date, approximately

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## Abstract In human neuroblastomas, the distal portion of 1p is frequently deleted, as if one or more tumor suppressor genes from this region were involved in neuroblastoma tumorigenesis. Earlier studies had identified a smallest region of overlapping deletion (SRO) spanning approximately 23 cM be