Intratumoural heterogeneity of 1p deletions andMYCN amplification in neuroblastomas
โ Scribed by Ambros, P.F. ;Ambros, I.M. ;Kerbl, R. ;Luegmayr, A. ;Rumpler, S. ;Ladenstein, R. ;Amann, G. ;Kovar, H. ;Horcher, E. ;De Bernardi, B. ;Michon, J. ;Gadner, H.
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 552 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0098-1532
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Amplification of the MYCN gene is significantly associated with an unfavorable prognosis and rapid progression in human neuroblastoma tumors. One potential mechanism by which MYCN may cause these effects is by deregulating cell proliferation. Tissue culture experiments support a model in which MYC g
## Background: We have identified for the first time a homozygously deleted region within the smallest region of overlap at 1p36.2-3 in two neuroblastoma cell lines. ## Procedure: The 800-kb pac contig covering the entire homozygously deleted region was made and sequenced. to date, approximately
## Abstract In human neuroblastomas, the distal portion of 1p is frequently deleted, as if one or more tumor suppressor genes from this region were involved in neuroblastoma tumorigenesis. Earlier studies had identified a smallest region of overlapping deletion (SRO) spanning approximately 23 cM be