## Abstract Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive degeneration of nigrostriatal dopaminergic (DA) neurons. The therapeutic potential of glial cell line‐derived neurotrophic factor (GDNF), the most potent neurotrophic factor for DA neurons, has been dem
✦ LIBER ✦
Intrastriatal glial cell line-derived neurotrophic factor promotes sprouting of spared nigrostriatal dopaminergic afferents and induces recovery of function in a rat model of Parkinson's disease
✍ Scribed by C Rosenblad; A Martinez-Serrano; A Björklund
- Book ID
- 117492027
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 250 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0306-4522
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## Abstract Glial cell line‐derived neurotrophic factor (GDNF) has been shown to be neuroprotective in animal models of the dopamine deficiency in Parkinson's disease. To examine the role of the extracellular signal‐regulated kinases 1 and 2 (ERK1/2) in this process, we infused a single dose of GDN