## Abstract ## Background: Glial cellโderived neurotrophic factor is a survival factor for dopaminergic neurons and a promising candidate for the treatment of Parkinson's disease. However, the delivery issue of the protein to the brain still remains unsolved. Our aim was to investigate the effect
Long-term effect of intra-striatal glial cell line-derived neurotrophic factor-releasing microspheres in a partial rat model of Parkinson's disease
โ Scribed by Christophe Jollivet; Anne Aubert-Pouessel; Anne Clavreul; Marie-Claire Venier-Julienne; Claudia N. Montero-Menei; Jean-Pierre Benoit; Philippe Menei
- Book ID
- 116766289
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 138 KB
- Volume
- 356
- Category
- Article
- ISSN
- 0304-3940
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## Abstract ## Background Efficient protection of dopaminergic neurons against a subsequent 6โhydroxydopamine lesion by glial cell lineโderived neurotrophic factor (GDNF) gene delivery has been demonstrated. By contrast, the neurorestorative effects of GDNF administered several weeks after the tox
## Abstract Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive degeneration of nigrostriatal dopaminergic (DA) neurons. The therapeutic potential of glial cell lineโderived neurotrophic factor (GDNF), the most potent neurotrophic factor for DA neurons, has been dem