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Intramolecular type-II "metallo-ene" reactions of (2-alkenylallyl)magnesium chlorides: regio- and stereochemical studies

โœ Scribed by Oppolzer, Wolfgang; Pitteloud, Rita; Strauss, Heinrich F.


Book ID
126324003
Publisher
American Chemical Society
Year
1982
Tongue
English
Weight
270 KB
Volume
104
Category
Article
ISSN
0002-7863

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Practical preparation and metallo-ene re
โœ Wolfgang Oppolzer; Philippe Schneider ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 212 KB

Magnesium activated by equilibratiog with its anthracene adduct in THF metalates smoothly 2-alkenyl chlorides at -65 C without significant coupling. The resulting solutions of Grignard reagents are subjected to thermal (80-130ยฐC) cyclization followed by trapping with electrophiles.