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Intramolecular palladium-catalyzed cyclization of methyl 1-(2-bromobenzyl)indole-2-carboxylates: Synthesis of pratosine and hippadine

✍ Scribed by Yasuyoshi Miki; Hideaki Shirokoshi; Ko-ichi Matsushita


Book ID
104261470
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
120 KB
Volume
40
Category
Article
ISSN
0040-4039

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Synthesis of 2-substituted-benzothiazole
✍ Carolina Benedı́; Fernando Bravo; Pedro Uriz; Elena FernΓ‘ndez; Carmen Claver; Se πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 157 KB

2-Amino-, and 2-alkyl-benzothiazoles have been efficiently prepared by palladium catalyzed cyclization of o-bromophenylthioureas and o-bromophenylthiamides. Results were best with the Pd 2 (dba) 3 /monophosphine catalytic system.