Intrahepatic transplantation of normal hepatocytes prevents Wilson's disease in Long-Evans cinnamon rats
β Scribed by Y Yoshida; Y Tokusashi; GH Lee; K Ogawa
- Book ID
- 118519646
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 856 KB
- Volume
- 111
- Category
- Article
- ISSN
- 0016-5085
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The disposition behaviors and de-coppering effect of triethylenetetramine dihydrochloride (trientine), a selective chelating agent for copper and an 'orphan drug' for Wilson's disease, have been evaluated in an animal model, Long-Evans Cinnamon (LEC) rats, and normal rats (Wistar). In LEC rats, urin
The outcome of consecutive hepatocyte transplants was explored in a rat model of Wilson's disease before the onset of fulminant hepatitis without preconditioning regimens. Rats received a high-copper diet in order to induce a rapid induction of liver failure. Sham-operated rats (15/15) developed jau