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Presence of ATP-dependent copper transport in the hepatocyte canalicular membrane of the long-evans cinnamon rat, an animal model of wilson disease

✍ Scribed by Yukihiko Adachi; Yoshifumi Okuyama; Hirohisa Miya; Toshinori Kamisako


Book ID
118567530
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
181 KB
Volume
26
Category
Article
ISSN
0168-8278

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The disposition behaviors and de-coppering effect of triethylenetetramine dihydrochloride (trientine), a selective chelating agent for copper and an 'orphan drug' for Wilson's disease, have been evaluated in an animal model, Long-Evans Cinnamon (LEC) rats, and normal rats (Wistar). In LEC rats, urin