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Interspecies Pharmacokinetics of Xymedon

✍ Scribed by V. I. Pogorel'tsev; S. Yu. Garmonov; O. V. Polekhina; V. S. Reznik

Book ID
106356861
Publisher
Springer US
Year
2005
Tongue
English
Weight
286 KB
Volume
140
Category
Article
ISSN
0007-4888

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Interspecies extrapolation of pharmacoki
Interspecies extrapolation of pharmacokinetics
✍ Curtis C. Travis; Robin K. White; Richard C. Ward 📂 Article 📅 1990 🏛 Elsevier Science 🌐 English ⚖ 1020 KB

The purpose of this paper is to use physiologically based pharmacokinetic models to demonstrate that if toxic response is a function of the time profile in physiological time of the concentration of the toxic moiety in the target tissue, then the appropriate interspecies scaling law for toxic compou