Pharmacokinetics of halofantrine in the
✍
Dion R. Brocks; Jason W. Toni
📂
Article
📅
1999
🏛
John Wiley and Sons
🌐
English
⚖ 129 KB
👁 2 views
The antimalarial drug, halofantrine, is chiral and is administered clinically as the racemate. In order to define the pharmacokinetic properties of halofantrine enantiomers in the rat, male Sprague-Dawley rats (264-311 g) were given halofantrine HCl orally (n = 5; 14 mg/kg) or intravenously (i.v.) (