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Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2

✍ Scribed by Robert J. Turesky; Anne Constable; Laurent B. Fay; F.Peter Guengerich


Book ID
117469502
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
146 KB
Volume
143
Category
Article
ISSN
0304-3835

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Capsaicin, the principal component of Capsicum fruits, strongly inhibited the in vitro mutagenic activity of five heterocyclic amines (HCAs) in Salmonella typhimurium strain TA98 by hamster liver microsomes. This correlated with the inhibition of microsome associated demethylation of methoxyresorufi