Recombinant human P450 forms 1A1, 1A2, and 1B1 catalyze the bioactivation of heterocyclic amine mutagens in Escherichia coli lacZ strains

The effects of capsaicin on the metaboli

The effects of capsaicin on the metabolic activation of heterocyclic amines and on cytochrome P450 1A2 activity in hamster liver microsomes

✍ Robert W. Teel; Zhuo Zhang; Huong Huynh; Solomon Hamilton 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 154 KB 👁 2 views

Capsaicin, the principal component of Capsicum fruits, strongly inhibited the in vitro mutagenic activity of five heterocyclic amines (HCAs) in Salmonella typhimurium strain TA98 by hamster liver microsomes. This correlated with the inhibition of microsome associated demethylation of methoxyresorufi