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Intermediacy of uro'gen III and of a heptacarboxylic uro'gen in corrinoid biosynthesis

✍ Scribed by Scott, A. Ian; Georgopapadakou, N.; Ho, K. S.; Klioze, S.; Lee, E.; Lee, S. L.; Temme, G. H.; Townsend, C. A; Armitage, I. M.

Book ID
126922056
Publisher
American Chemical Society
Year
1975
Tongue
English
Weight
353 KB
Volume
97
Category
Article
ISSN
0002-7863

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Synthesis of a novel tetrapyrrolic macro
Synthesis of a novel tetrapyrrolic macrolactam and its activity towards Uro'gen III synthase
✍ Clotilde Pichon; A. Ian Scott πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 869 KB

## Abstract A novel macrocyclic tetrapyrrolelactam 8, analog of a putative intermediate, has been synthesized. Its very low inhibitory effect on Uro'gen III synthase renders it unlikely to be a low‐energy transition‐state analog.