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Interleukin-12 abrogates the effector functions of regulatory T cells in an experimental colitis

✍ Scribed by Liu, Zhanju; Maerten, Phillippe; Colpaert, Stefaan; Ceuppens, Jan L.; Rutgeerts, Paul

Book ID
124132561
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
190 KB
Volume
120
Category
Article
ISSN
0016-5085

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IL-12 promotes Th1 cell differentiation and cell-mediated immunity. In the present study, the potential role of IL-12 was analyzed in an experimental colitis model in scid mice reconstituted with syngeneic CD45RB high CD4 + T cells. Real-time reverse transcription-PCR studies demonstrated that IL-12