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Interleukin-1 Specifically Increases Substance P in Injured Sympathetic Ganglia

✍ Scribed by G. MILLER JONAKAIT; SANDRA SCHOTLAND; RONALD P. HART

Book ID
119865053
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
633 KB
Volume
594
Category
Article
ISSN
0890-6564

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πŸ“œ SIMILAR VOLUMES

Conditioned medium from activated spleno
Conditioned medium from activated splenocytes increases substance P in sympathetic ganglia
✍ G. Miller Jonakait; S. Schotland πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 675 KB

We report here that SP increases dramatically in cultures of SCG grown in the presence of conditioned medium from con-A-stimulated splenocytes. The effect is mimicked by growing SCG explants in the presence of human recombinant interleukin-1 (hrIL-1) but not hrIL-2. Nerve growth factor (NGF) is not

The interleukin-1-induced increase of su
The interleukin-1-induced increase of substance P in sympathetic ganglia is not mediated by ciliary neurotrophic factor
✍ M. Ding; R. P. Hart; A. M. Shadiack; Dr. G. M. Jonakait πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 939 KB

Interleukin-1 (IL-1) induction of substance P (SP) in cultured sympathetic ganglia requires a soluble intermediate molecule that is present in IL-1 conditioned medium (IL-1CM). One of the required intermediates is leukemia inhibitory factor (LIF; Shadiack et al., J Neurosci 13:2601-2609, 1993). In t

Tumor necrosis factor-Ξ± induces substanc
Tumor necrosis factor-Ξ± induces substance P in sympathetic ganglia through sequential induction of interleukin-1 and leukemia inhibitory factor
✍ Ding, Minzhen ;Hart, Ronald P. ;Miller Jonakait, G. πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 864 KB

## Abstract The present study establishes that tumor necrosis factor‐α (TNF‐α) induction of sympathetic substance P (SP) requires sequential induction of both interleukin (IL‐1) and leukemia inhibitory factor (LIF). TNF‐α dose‐dependently induces SP, an induction that is secondory to an increase in