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Interleukin-1 blockade in rheumatoid arthritis and heart failure: A missed opportunity?

✍ Scribed by Abbate, Antonio; Canada, Justin M.; Van Tassell, Benjamin W.; Wise, Christopher M.; Dinarello, Charles A.

Book ID
121653241
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
192 KB
Volume
171
Category
Article
ISSN
0167-5273

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## Abstract ## Objective Interleukin‐21 (IL‐21) is a T cell–derived cytokine that modulates T cell, B cell, and natural killer cell responses. In this study, the effects of blocking IL‐21 were examined in 2 rodent models of rheumatoid arthritis (RA) to determine whether IL‐21 contributes to their