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Interleukin-6 Receptor Blockade Enhances CD39+ Regulatory T Cell Development in Rheumatoid Arthritis and in Experimental Arthritis

✍ Scribed by Thiolat, A.; Semerano, L.; Pers, Y. M.; Biton, J.; Lemeiter, D.; Portales, P.; Quentin, J.; Jorgensen, C.; Decker, P.; Boissier, M.-C.; Louis-Plence, P.; Bessis, N.


Book ID
125504565
Publisher
Wiley (John Wiley & Sons)
Year
2014
Tongue
English
Weight
416 KB
Volume
66
Category
Article
ISSN
2326-5191

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Clonally expanded CD4+CD28null T cells i
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Clonally expanded, autoreactive CD4(+)CD28(null) cells can be found in the peripheral blood of patients with rheumatoid arthritis and have been shown to be associated with severeextra-articular disease manifestations. We investigated the size of the CD4(+)CD28(null) compartment and the TCR beta chai