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Interferon induces cell fusion and the formation of multinuclear cells in a culture of ehrlich ascites tumor cells

✍ Scribed by Shin-Ichi Tominaga

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 629 KB
Volume: 135
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041350225

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✦ Synopsis

The increase in number of Ehrlich ascites tumor (EAT) cells was diminished significantly when the cell culture was treated with 1,000 IU/ml of recombinant mouse alpha or beta interferon (IFN). Microscopical observation revealed that almost all the cells showed bi-or multinuclear morphology 3 to 5 days after IFN treatment. Furthermore, a videorecording showed that each multinuclear cell arose by fusion after mitotic division of one parental cell.

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