Interferon alpha-2a and 5-fluorouracil for advanced colorectal carcinoma assessment of activity and toxicity
โ Scribed by Nancy Kemeny; Anas Younes; Karen Seiter; David Kelsen; Patricia Sammarco; Lynn Adams; Susan Derby; Peggy Murray; Collette Houston
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 621 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0008-543X
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๐ SIMILAR VOLUMES
Background. Potential synergy between 5-fluorouracil (5-FU) and interferon alpha-2a (IFN-a-Za) has been demonstrated in the treatment of colorectal carcinoma. Continuous low-dose infusion of 5-FU may have superior response rates to bolus 5-FU in these malignancies. This report presents results of tw
disease progression. IFN was administered subcutaneously three times weekly at for the Groupe d'Etude et de a dose of 3 MU (body surface area [BSA] รต 1.75 m 2 ) or 4.5 MU (BSA ยข 1.75 m 2 ). Recherche sur les Cancers de RESULTS. World Health Organization toxicity Grade 3-4 occurred in 21 patients l'O