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Interconversion between local lymph node assay EC3 units

✍ Scribed by David W. Roberts

Book ID
109380872
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
441 KB
Volume
65
Category
Article
ISSN
0105-1873

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A comparison of statistical approaches to the derivation of EC3 values from local lymph node assay dose responses
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The murine local lymph node assay (LLNA) was developed as an alternative method for the identification of chemicals that have the ability to cause skin sensitization and allergic contact dermatitis. The assay now has been evaluated extensively in the context of both national and international inter-

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## Abstract The local lymph node assay (LLNA) is a skin sensitization test that provides animal welfare benefits. To reduce animal usage further, a modified version (rLLNA) was proposed. Conducting the rLLNA as a screening test with a single high dose group and vehicle control differentiated accura