A murine local lymph node assay has been developed for the identification of contact sensitizing chemicals. In the present study, the performance of the local lymph node assay has been evaluated with twenty-four coded chemicals of previously unknown skin sensitizing potential and the results compar
Draining lymph node cell activation in guinea pigs: Comparisons with the murine local lymph node assay
β Scribed by Thomas Maurer; Ian Kimber
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 504 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0300-483X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Guineaβpig lymphβnode cells (LNC) cultured for 5 days in medium containing fetal calf serum (FCS) were cytotoxic to various target cells. LNC cultured in medium supplemented with fresh, autologous guineaβpig serum (GPS) instead of FCS were not detectably cytotoxic unless agents that sti
The murine local lymph node assay is a predictive method for the identification of skin-sensitizing chemicals in which activity is measured as a function of proliferative activity induced in lymph nodes draining the site of exposure. In the present study, the induction by topically applied chemicals
## Abstract The murine local lymph node assay, an alternative predictive test for the identification of contact sensitizing chemicals, is based upon the fact that skin allergens induce proliferation in lymph nodes draining the site of application. In the present study we have examined whether preβe
## Abstract Allergic contact dermatitis is the serious unwanted effect arising from the use of consumer products such as cosmetics. Isoeugenol is a fragrance chemical with spicy, carnationβlike scent, is used in many kinds of cosmetics and is a wellβknown moderate human sensitizer. It was previousl