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Interactions of drugs with proteins I: Binding of tricyclic thymoleptics to human and bovine plasma proteins

✍ Scribed by H. J. Weder; M. H. Bickel

Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
317 KB
Volume
59
Category
Article
ISSN
0022-3549

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✦ Synopsis

Data on the binding of imipramine, desipramine, and 3-chlorodesmethylimipramine to plasma proteins have been obtained over a wide range of ligand concentration using a modified equilibrium dialysis technique. Plasma proteins other than albumin do not appreciably contribute to complex formation with the drugs studied. Fifty-nine percent imipramine is bound to albumin in the plasma level range reached under therapeutic conditions. However, the association constants of the complex is low. Species differences in the binding capacity of albumin were observed. Apparently, atypical binding behavior was disclosed for desipramine and 3-chlorodesmethylimipramine. A binding model is discussed, and values of binding parameters are given.

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