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Interactions of aminoglycoside antibiotics with phospholipids. A deuterium nuclear magnetic resonance study

✍ Scribed by André Schanck; Marie-Paule Mingeot-Leclercq; Paul M. Tulkens; Danielle Carrier; Ian C.P. Smith; Harold C. Jarrell

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
860 KB
Volume
62
Category
Article
ISSN
0009-3084

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✦ Synopsis

The effect of ~,eral aminoglycmide (AG) antibiotic8 on aqueous muitilamellar dispersions of mixtures of phosphatid~linositoi (PI) and deuterated phmphafidylcholine (PC') has been studied by deuterium (2H) NMR. Isepandcin and amikachl gave rise to no significant changes in 2H-NMR fineshape relative to that of the lipid mixture without antibiotic. Both kanamycin A and B, which have a greater aflVmity for Pl than the other two antibiotics examined in this study, induced temperature-dependent changes in 2H-NMR lineld~q~es and a~ciated spectral moments. The results are consistent with an antibiotic-induced lateral phase separation giving rise to PC_.-enfid~ domains free of drug and PI-AG domains. These effects are correlated with the inhibitory potency of aminoglycusides towar~ PC degradation.

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