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Interactions of aminoglycosides with phosphatidylinositol: A 15N nuclear magnetic resonance study

✍ Scribed by André Schanck; Robert Brasseur; Marie-Paule Mingeot-Leclercq; Paul M. Tulkens

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
464 KB
Volume
30
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

The ^15^N NMR spectra of eight aminoglycosides were interpreted. The effect of mixing 20 mol.% of various aminoglycosides with phosphatidylinositol in aqueous dispersion was studied by ^15^N NMR, and correlations were found between the degree of interaction of the aminoglycoside for phosphatidylinositol and the calculated energy of interaction of the antibiotic with the negatively charged phospholipid and the inhibitory potency of the drug towards lysosomal phospholipase A~1~, a critical parameter in the nephrotoxic potential of aminoglycosides.

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