Interaction of strain and interleukin-1 in articular cartilage: effects on proteoglycan synthesis in chondrocytes
β Scribed by Robert J. Gassner; Michael J. Buckley; Rebecca K. Studer; Chris H. Evans; Sudha Agarwal
- Book ID
- 114422214
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 151 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0901-5027
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Interleukin-6 (IL-6) levels are markedly increased in the synovial fluid of patients with rheumatoid arthritis or osteoarthritis. However, the effects of IL-6 on proliferation and proteoglycan metabolism in articular cartilage are not known. We demonstrated here the effects of human recombinant (hr)
Objective. To study the effect of bone morphogenetic protein 2 (BMP-2) on articular cartilage proteoglycan (PG) synthesis in vivo and to investigate whether BMP-2 is able to counteract the effects of interleukin-1 (IL-1) on articular cartilage PG synthesis and content. Methods. BMP-2 alone or in co