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Interaction of p14ARF with Brca1 in cancer cell lines and primary breast cancer

✍ Scribed by Lizhi He; Catherine Fan; Xiaoming Ning; Xinchang Feng; Yun Liu; Biao Chen; Damu Tang

Book ID
108084655
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
526 KB
Volume
32
Category
Article
ISSN
1065-6995

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A competitive polymerase chain reaction has been developed for quantitation of BRCA1 mRNA. In human cancer cell lines, the amount of BRCA1 mRNA is relatively low, ranging from 6 to 38 copies per cell. The decay rate of these transcripts in actinomycin-treated cells indicates that the half-life of th