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Interaction of doxorubicin and its derivatives with DNA: Elucidation by resonance Raman and surface-enhanced resonance Raman spectroscopy

✍ Scribed by Qing Yan; Waldemar Priebe; Jonathan B. Chaires; Roman S. Czernuszewicz

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
260 KB
Volume
3
Category
Article
ISSN
1075-4261

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✦ Synopsis

The interactions of doxorubicin and its derivatives, hydroxyrubicin and adriamycinone, with DNA were studied by resonance Raman (RR) and surface-enhanced resonance Raman scattering (SERRS) spectroscopy. The p-p interaction between the chromophore of the drug and DNA base pairs has been shown to downshift the skeletal stretching mode Γ‡ 1440 cm 01 by 8, 5, and 4 cm 01 for doxorubicin, hydroxyrubicin, and adriamycinone, respectively. The additional effects of intercalation with DNA on the RR and SERRS spectra for hydroxyrubicin are similar to those for doxorubicin. However, different effects are observed for adriamycinone. These results indicate that the sugar moiety is necessary to maintain the maximum van der Waals contact between the chromophore and the DNA base pairs and that the amine group in the amino sugar is more favored than the hydroxyl group.

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