Interaction of DNA with Bis(diiminosuccinonitrilo)platinum(II)

✍ Scribed by Zhi-Gang ZHANG; Yuan-Yuan SUN; Xiao-Ming JIANG

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 102 KB
• Volume: 26
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.200890087

✦ Synopsis

Abstract

Interaction of DNA with bis(diiminosuccinonitrilo)platinum(II) has been studied by UV‐visible absorbance spectra, fluorescence spectra and viscosity measurements. The UV‐visible absorption spectra of the metal complex exhibit hypochromism with a small blue shift on interaction with DNA. Scatchard plot analyses indicate that the binding sites of the metal complex on DNA are different from those of ethidium bromide. Viscosity experiments reveal that the binding of the metal complex decreases the relative viscosity of DNA. These results suggest that the platinum diimine complex interact with DNA by surface binding. These studies are helpful for us to understand the action mechanism ofbis(diiminosuccinonitrilo)platinum(II) as a potential photodynamic therapeutic agent, and further to develop it.