Interaction between estrogen receptor 1 and the ε4 allele of apolipoprotein E increases the risk of familial Alzheimer's disease in women
✍ Scribed by Kari M Mattila; Karin Axelman; Juha O Rinne; Mari Blomberg; Terho Lehtimäki; Pekka Laippala; Matias Röyttä; Matti Viitanen; Lars-Olof Wahlund; Bengt Winblad; Lars Lannfelt
- Book ID
- 117470521
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 90 KB
- Volume
- 282
- Category
- Article
- ISSN
- 0304-3940
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## Abstract ## Objectives To assess the association between testosterone levels and __APOE__ε4 in cases with AD and controls. ## Method We included 61 men with definite or probable Alzheimer's disease (AD) and 55 elderly male controls from the Oxford Project to Investigate Memory and Ageing (OPT
A strong association has been described in cross-sectional studies between the ~4 allele of the apolipoprotein E and late-onset Alzheimer's disease (LOAD). This study addresses the relationship between disease progression and the ~4 allele in 6 2 sporadic LOAD (onset at age 70 and over) patients. Di