𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Apolipoprotein E ε4 and testosterone interact in the risk of Alzheimer's disease in men

✍ Scribed by E. Hogervorst; D. J. Lehmann; D. R. Warden; J. McBroom; A. D. Smith

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
42 KB
Volume
17
Category
Article
ISSN
0885-6230

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Objectives

To assess the association between testosterone levels and __APOE__ε4 in cases with AD and controls.

Method

We included 61 men with definite or probable Alzheimer's disease (AD) and 55 elderly male controls from the Oxford Project to Investigate Memory and Ageing (OPTIMA). Testosterone was measured using a competitive enzyme immunoassay (Bayer®).

Results

We found that both low serum testosterone and the interaction between testosterone and __APOE__ε4 were associated with AD. Furthermore, testosterone levels were lower in __APOE__ε4‐positive controls (mean: 11.3 nmol/L) than in controls without the allele (19.1 nmol/L).

Conclusions

Low testosterone is potentially a modifiable risk factor, which may prove relevant to __APOE__ε4 carriers who are at risk of AD. Copyright © 2002 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Apolipoprotein E-η4 allele and familial
Apolipoprotein E-η4 allele and familial risk in Alzheimer's disease
✍ Ge Li; Jeremy M. Silverman; Larry D. Altstiel; Vahram Haroutunian; Daniel P. Per 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 910 KB

Recent studies have 'found an association between presence of apolipoprotein E (APOE) €4 allele and Alzheimer's disease (AD). The present study compared the cumulative risk of primary progressive dementia (PPD) in relatives of AD probands carrying at least one copy of the €4 allele with the relative