Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
β Scribed by Corder, E.; Saunders, A.; Strittmatter, W.; Schmechel, D.; Gaskell, P.; Small, G.; Roses, A.; Haines, J.; Pericak-Vance, M.
- Book ID
- 111882315
- Publisher
- American Association for the Advancement of Science
- Year
- 1993
- Tongue
- English
- Weight
- 803 KB
- Volume
- 261
- Category
- Article
- ISSN
- 0036-8075
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A strong association has been described in cross-sectional studies between the ~4 allele of the apolipoprotein E and late-onset Alzheimer's disease (LOAD). This study addresses the relationship between disease progression and the ~4 allele in 6 2 sporadic LOAD (onset at age 70 and over) patients. Di
Recent studies have 'found an association between presence of apolipoprotein E (APOE) β¬4 allele and Alzheimer's disease (AD). The present study compared the cumulative risk of primary progressive dementia (PPD) in relatives of AD probands carrying at least one copy of the β¬4 allele with the relative