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Interaction between cAMP-dependent Protein Kinase Catalytic Subunit and Peptide Inhibitors Analyzed with λ Repressor Fusions

✍ Scribed by Roberto Jappelli; Sydney Brenner


Book ID
115627404
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
158 KB
Volume
259
Category
Article
ISSN
0022-2836

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## Abstract The active site of the mammalian cAMP‐dependent protein kinase catalytic subunit (C‐subunit) has a cluster of nonconserved acidic residues—Glu127, Glu170, Glu203, Glu230, and Asp241—that are crucial for substrate recognition and binding. Studies have shown that the Glu230 to Gln mutant