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Solution structure of the cAMP-dependent protein kinase catalytic subunit and its contraction upon binding the protein kinase inhibitor peptide

✍ Scribed by Olah, G. A.; Mitchell, R. D.; Sosnick, T. R.; Walsh, D. A.; Trewhella, J.


Book ID
125940328
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
1000 KB
Volume
32
Category
Article
ISSN
0006-2960

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## Abstract The active site of the mammalian cAMP‐dependent protein kinase catalytic subunit (C‐subunit) has a cluster of nonconserved acidic residuesβ€”Glu127, Glu170, Glu203, Glu230, and Asp241β€”that are crucial for substrate recognition and binding. Studies have shown that the Glu230 to Gln mutant