E230Q mutation of the catalytic subunit
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Man-Un Ung; Benzhuo Lu; J. A. McCammon
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Article
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2006
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Wiley (John Wiley & Sons)
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English
β 484 KB
π 2 views
## Abstract The active site of the mammalian cAMPβdependent protein kinase catalytic subunit (Cβsubunit) has a cluster of nonconserved acidic residuesβGlu127, Glu170, Glu203, Glu230, and Asp241βthat are crucial for substrate recognition and binding. Studies have shown that the Glu230 to Gln mutant