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Intensive immunosuppression with cyclophosphamide in multiple sclerosis

✍ Scribed by R. E. Gonsette; L. Demonty; P. Delmotte

Publisher
Springer
Year
1977
Tongue
English
Weight
440 KB
Volume
214
Category
Article
ISSN
0340-5354

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✦ Synopsis

140 MS patients were treated with intensive I.V. cyclophosphamide immunotherapy and 110 were followed over 2-4 years. Annual relapse rate incidence was calculated over a period of 2 years before and after treatment and repeated neurological scores were made during this period. The conclusions are that 62% of the patients were stabilized during 2-4 years and that clinical improvement of the neurological signs was observed in most of the cases. It is concluded that intensive immunosuppression is able to interfere with the pathological processes involved in the pathogenesis of disseminated sclerosis.

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