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Integrin-nucleated Toll-like receptor (TLR) dimerization reveals subcellular targeting of TLRs and distinct mechanisms of TLR4 activation and signaling

✍ Scribed by Haifeng Zhang; Puei Nam Tay; Weiping Cao; Wei Li; Jinhua Lu


Book ID
117104904
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
193 KB
Volume
532
Category
Article
ISSN
0014-5793

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## Abstract Severe injury deranges immune function and increases the risk of sepsis and multiple organ failure. Kupffer cells play a major role in mediating posttraumatic immune responses, in part via different Toll‐like receptors (TLR). Although mitogen‐activated protein kinases (MAPK) are key ele