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Toll-like receptor 9 (TLR9) activation attenuates TLR4-mediated signaling in enterocytes and reduces the severity of experimental necrotizing enterocolitis

✍ Scribed by Steven C. Gribar; Ward M. Richardson; Jeffrey W. Kohler; Maria F. Branca; Theresa D. Dubowski; Jun Li; Chhinder P. Sodhi; David J. Hackam


Book ID
113678675
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
47 KB
Volume
207
Category
Article
ISSN
1072-7515

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## Abstract Severe injury deranges immune function and increases the risk of sepsis and multiple organ failure. Kupffer cells play a major role in mediating posttraumatic immune responses, in part via different Toll‐like receptors (TLR). Although mitogen‐activated protein kinases (MAPK) are key ele