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Integrin-Mediated Adhesion and Signalling in Ovarian Cancer Cells

โœ Scribed by Jo Ann Buczek-Thomas; Norah Chen; Tayyaba Hasan


Book ID
114284074
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
488 KB
Volume
10
Category
Article
ISSN
0898-6568

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## Abstract In metastatic cancer, high expression levels of vitronectin (VN) receptors (integrins), FAK, and ERK5 are reported. We hypothesized that integrinโ€mediated ERK5 activation via FAK may play a pivotal role in cell adhesion, motility, and metastasis. ERK5 and FAK phosphorylation when metast