The present study correlates the insulin resistance seen in the myocardium of rats with streptozotocin-induced non-insulin-dependent diabetes mellitus with insulin secretory defects, hyperglycaemia and disease duration. Two-day-old male Wistar rats were given a bolus injection of streptozotocin (0.0
✦ LIBER ✦
Insulitis and mechanisms of disease resistance: studies in an animal model of insulin dependent diabetes mellitus
✍ Scribed by A. J. Bone; P. R. Hitchcock; D. J. Gwilliam; J. M. Cunningham; J. Barley
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 104 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0946-2716
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Correlation studies between cytokines expressed in islets and autoimmune diabetes development in NOD mice and BB rats have demonstrated that -cell destructive insulitis is associated with increased expression of proinflammatory cytokines (IL-1, TNF␣, and IFN␣) and type 1 cytokines (IFN␥, TNF, IL-2