✦ LIBER ✦

Insulin resistance and mechanical dysfunction in hearts of Wistar rats with streptozotocin-induced non-insulin-dependent diabetes mellitus

✍ Scribed by S. W. Schaffer; G. L. Wilson

Publisher: Springer
Year: 1993
Tongue: English
Weight: 483 KB
Volume: 36
Category: Article
ISSN: 0012-186X
DOI: 10.1007/bf00399949

No coin nor oath required. For personal study only.

✦ Synopsis

The present study correlates the insulin resistance seen in the myocardium of rats with streptozotocin-induced non-insulin-dependent diabetes mellitus with insulin secretory defects, hyperglycaemia and disease duration. Two-day-old male Wistar rats were given a bolus injection of streptozotocin (0.09 mg/g body weight) which caused glucose intolerance when these animals reached adulthood. Although these rats developed a progressive resistance to the actions of insulin in the heart this did not correlate with the development of glucose intolerance. However, a correlation was seen with a shift in insulin secretory response from hyper- to hypo-secretion which developed between 6 and 14 months of age. Moreover, this shift in secretory pattern can be associated with the onset of a cardiac mechanical malfunction.

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