The present study correlates the insulin resistance seen in the myocardium of rats with streptozotocin-induced non-insulin-dependent diabetes mellitus with insulin secretory defects, hyperglycaemia and disease duration. Two-day-old male Wistar rats were given a bolus injection of streptozotocin (0.0
Insulin restores expression of adenosine kinase in streptozotocin-induced diabetes mellitus rats
β Scribed by Monika Sakowicz; Tadeusz Pawelczyk
- Book ID
- 110346031
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 107 KB
- Volume
- 236
- Category
- Article
- ISSN
- 0300-8177
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## Abstract The pharmacokinetic parameters of 5βfluorouracil were compared after intravenous administration at a dose of 30 mg/kg to control SpragueβDawley rats and to rats with diabetes mellitus induced by streptozotocin (DMIS). In DMIS rats, the area under the plasma concentrationβtime curve from
## Abstract ## Background Adenosine A1 receptor (A1βAR) activation can lower plasma glucose in diabetic rats lacking insulin. We investigated the change in A1βAR gene expression in diabetic rats. ## Methods The incorporation of [Uβ^14^C]βglucose into glycogen was carried out to evaluate the effe