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Insulin-releasing action of the novel antidiabetic agent BTS 67 582

โœ Scribed by Neville H. McClenaghan; Peter R. Flatt; Clifford J. Bailey

Book ID
110003408
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
322 KB
Volume
123
Category
Article
ISSN
0007-1188

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Investigation of the effects of BTS 67 5
Investigation of the effects of BTS 67 582, a novel antidiabetic agent, in the beagle dog
โœ M.J. Cooling; P. Spencer; D. Yates; M.F. Sim; R.B. Jones ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 167 KB

BTS 67 582 stimulates insulin release and causes dose-dependent glucose-lowering activity in the conscious beagle dog. Plasma glucose levels were lowered within 1 h and were maximally reduced by 53.2 ยฑ 2.7% 2-3 h after oral dosing with 90 ยตmol/kg BTS 67 582 (equivalent to 22.5 mg/kg as the free base