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Insulin-like growth factor receptor polymorphism defines clinical outcome in estrogen receptor-positive breast cancer patients treated with tamoxifen

✍ Scribed by Winder, T; Giamas, G; Wilson, P M; Zhang, W; Yang, D; Bohanes, P; Ning, Y; Gerger, A; Stebbing, J; Lenz, H-J


Book ID
120047091
Publisher
Nature Publishing Group
Year
2013
Tongue
English
Weight
403 KB
Volume
14
Category
Article
ISSN
1470-269X

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The insulin-like growth factors (IGFs) have been implicated in the growth regulation of human breast cancer. Since the lCFs are associated with specific binding proteins (ICFBPs) which may modulate receptor/ligand interactions, production of IGFBPs by breast cancer cells could alter their IGF-depend