## Abstract Seventy to 40% of K‐RAS wild type colorectal tumors does not seem to benefit from treatment with antiepidermal growth factor receptor (anti‐EGFR) monoclonal antibodies. Recent data suggested that in presence of IGF‐1 system, altered activation colorectal cancer cells may escape anti‐EGF
Insulin-like growth factor receptor 1 pathway signature correlates with adverse clinical outcome in ovarian cancer
✍ Scribed by B. Winterhoff; P. Haluska; K. Kalli; W. Cliby; B. Gostout; A. Oberg; M. Maurer; L. Hartmann; D. Slamon; G. Konecny
- Book ID
- 113962895
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 108 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0090-8258
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## Abstract ## BACKGROUND. Cleavage of membrane‐anchored heparin‐binding epidermal growth factor‐like growth factor (proHB‐EGF) yields a soluble HB‐EGF isoform (sHB‐EGF), which is an activating epidermal growth factor receptor (EGFR) ligand and a C‐terminal fragment HB‐EGF‐C acting directly in the