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Insulin-like growth factor-II as a prognostic factor in pulmonary adenocarcinoma

✍ Scribed by Takanami, Iwao; Imamuma, Tetsuo; Hashizume, Toshinori; Kikuchi, Keiichi; Yamamoto, Yasuki; Yamamoto, Tatsuya; Kodaira, Susumu

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
353 KB
Volume
61
Category
Article
ISSN
0022-4790

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✦ Synopsis

We stained resected specimens from 117 patients with pulmonary adenocarcinoma for insulin-like growth factor-I1 (IGF-11) by the avidin-biotinperoxidase (ABC) method and evaluated the usefulness of IGF-I1 as a prognostic factor. The patients were classified into the IGF-I1 (+) groups showing staining of 1% or more cancer cells (60 patients) and the IGF-I1 (-) groups showing staining of < 1 % (57 patients). The 5-year survival rate was 22% in the IGF-I1 (+) group and 54% in the IGF-I1 (-) group (P < 0.01). Our results suggest the usefulness of IGF-I1 stainability as a prognostic factor of pulmonary adenocarcinoma.

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