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Usefulness of platelet-derived growth factor as a prognostic factor in pulmonary adenocarcinoma

✍ Scribed by Iwao Takanami; Yasuki Yamamoto; Susumu Kodaira; Tetsuo Imamura

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
435 KB
Volume
58
Category
Article
ISSN
0022-4790

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✦ Synopsis

Platelet-derived growth factor (PDGF) in the resected pulmonary adenocarcinoma tissue of 88 patients was detected immunohistochemically by the avidin-biotin-peroxidase technique to determine whether or not it is a prognostic parameter. The 88 patients were divided into PDGF (-) and PDGF (+) groups according to the stainability of the factor. The PDGF (-) group included 39 patients and the PDGF (+) group 49. The 5-year survival rate was 53% for the PDGF (-) group and 17% for the PDGF (+) group (P < 0.01). These findings indicate that the stainability of PDGF can be a prognostic parameter for pulmonary adenocarcinoma.

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