✦ LIBER ✦

Prognostic significance of insulin-like growth factor II mRNA-binding protein 3 expression in gastric adenocarcinoma

✍ Scribed by Y.-M. Jeng; T.-H. Wang; S.-H. Lu; R.-H. Yuan; H.-C. Hsu

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 262 KB
Volume: 96
Category: Article
ISSN: 0007-1323
DOI: 10.1002/bjs.6438

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

Insulin-like growth factor II mRNA-binding protein (IMP) 3 is expressed in embryonic tissues and multiple cancers. The aim was to establish the prognostic value of IMP-3 expression in gastric adenocarcinoma.

Methods

IMP-3 expression in resected gastric adenocarcinomas was analysed by immunohistochemistry.

Results

IMP-3 was expressed in 183 (58·1 per cent) of 315 tumours. Expression was associated with older age (P < 0·001), larger tumour size (P = 0·009), deep tumour invasion (P < 0·001) and lymph node metastasis (P < 0·001). IMP-3-positive tumours were associated with poorer 5-year survival than negative tumours at all stages (stage I, 82 versus 97 per cent; stage II, 55 versus 78 per cent; stage III and IV, 11 versus 25 per cent; P = 0·005, P = 0·033 and P = 0·036 respectively). Multivariable analysis identified IMP-3 (hazard ratio (HR) 1·93), depth of tumour invasion (HR 3·69, 9·77 and 10·69 for pathological tumour stage (pT) 2, pT3 and pT4 respectively versus pT1), and lymph node metastasis (HR 1·57, 3·29 and 3·40 for pathological node stage (pN) 1, pN2 and pN3 respectively versus pN0) as independent prognostic factors.

Conclusion

IMP-3 expression correlates with the metastatic potential of gastric adenocarcinoma and is an independent prognostic factor.

📜 SIMILAR VOLUMES

Growth factor regulation of insulin-like

Growth factor regulation of insulin-like growth factor binding protein-6 expression in osteoblasts

✍ Bari Gabbitas; Ernesto Canalis 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 238 KB 👁 2 views

Previously we have shown that transforming growth factor b (TGF b) 1, basic fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF) BB inhibit the synthesis of insulin-like growth factor (IGF) II, but their effects on IGF binding protein (IGFBP)-6 in osteoblast cultures are not kno

Expression of insulin-like growth factor

Expression of insulin-like growth factor-binding protein messenger RNAs in developing rat oligodendrocytes and astrocytes

✍ Reema Mewar; F. Arthur McMorris 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 90 KB 👁 1 views

Insulin-like growth factors, IGF-I and IGF-II, are potent regulators of oligodendrocyte development. Most of the IGF present in vivo is bound to members of a family of six high-affinity IGF-binding proteins (IGFBPs), which can either potentiate or inhibit IGF action, depending on other conditions. A

Synthesis of insulin-like growth factor

Synthesis of insulin-like growth factor binding protein 3 in vitro in human articular cartilage cultures

✍ Tamar Eviatar; Hannah Kauffman; Alice Maroudas 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 221 KB 👁 1 views

The expression of insulin-like growth fa

The expression of insulin-like growth factor and its binding protein mRNA in the endometrium of postmenopausal patients with breast cancer receiving tamoxifen

✍ Timo J. Laatikainen; Eija I. Tomás; Raimo J. Voutilainen 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 482 KB 👁 2 views

Expression and release of insulin-like g

Expression and release of insulin-like growth factor binding proteins in isolated epiphyseal growth plate chondrocytes from the ovine fetus

✍ P. De Los Rios; D.J. Hill 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 223 KB 👁 2 views

Insulin-like growth factor-II (IGF-II) is an autocrine modulator of epiphyseal chondrogenesis in the fetus. The cellular availability of IGFs are influenced by the IGF-binding proteins (IGFBPs). In this study, we investigated the control of expression and release of IGFBPs from isolated epiphyseal g

Expression of insulin-like growth factor

Expression of insulin-like growth factor binding protein-3 (IGFBP-3) in human keratinocytes is regulated by EGF and TGFβ1

✍ Stephanie R. Edmondson; Mari M. Murashita; Vincenzo C. Russo; Christopher J. Wra 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 195 KB 👁 2 views

Insulin-like growth factor-I (IGF-I) is essential for normal epidermal homeostasis; however, the role of IGF binding proteins (IGFBPs), regulators of IGF action, remains unclear. Here we examine the regulation of human keratinocyte-produced IGFBPs by epidermal growth factor (EGF), transforming growt